Thursday, May 27


14.00 - 17.00     Registration


17.45 – 18.30    Introductory remarks:    Littarru GP - CoQ10, Historic overview and current topics


19.00                   Welcome reception


Friday, May 28


Mitochondrial Bioenergetics and non Mitochondrial Electron Transport

Chairpersons: Lenaz G. and Navas P.


08.30               Genova ML

                           Organization of mitochondrial respiratory complexes:

                           a new  understanding of an old subject


08.50              Morre J

                          Coenzyme Q inhibition of age-related NADH oxidase (arNOX).  

                          mechanisms and clinical implications


09.10              Bernardi P

                          Modulation of the  mitochondrial permeability transition by quinones


09.30              Greci L.

                          Is the isoprenic chain of coenzyme Q10 and its analogues involved in  their reactivity

                          with nitric oxide and nitrogen dioxide?


09.50 -10.05 Discussion

10.05–10.25Coffee break


Regulatory & Market Developments for CoQ10

Chairpersons: Van Camp J and Pettman S


10.25           Pettman S

                       Global regulatory overview


10.50           Wesolowska A/ Hosoe K

                       Scientific substantiation for the health claims on Coenzyme Q10 


11.10           Chmelik S

                       New market developments 


11.30           Littarru GP

                       Biochemical effects of CoQ10 enriched foods.


11.50           Panel Discussion with  Van Camp J, Pettman S, Chmelik S & Littaru GP


12.30 –14.30     Lunch  and Poster Session 1


Metabolic Aspects

Chairpersons: Delzenne N and Brismar K


14.30          Testa R

                      Metabolic determinants of plasma coenzyme Q10 in diabetes mellitus


14.50          Delzenne N

                      CoQ10, obesity and metabolic syndrome : an open door for the future?


15.10           Doring F

                      Influence of ubiquinol on inflammation and cholesterol metabolism transcriptomic and

                      metabolomic approaches


15.30           Casteilla L

                      CoQ, adipocytes and obesity


15.50 – 16.10        Discussion

16.10 - 16.30        Coffee break


Metabolic Aspects 2

Chairpersons: Pincemail J and Doring F


16.30        Prolla TA

                   The effects of Coenzyme Q10 on age-related gene expression changes in the brain

                   and age-related hearing loss


16.50        Brismar K

                   Treatment with CoQ10 influences the immune system differently in type 1 and type 2 diabetes


17.10        Yamamoto Y

                   Saposin B and its precursor prosaposin play key roles in absorption and transfer of CoQ10


17.30 – 17.45 Discussion

17.45 -18.15  -  Selected oral presentations from posters, 10‘ each


Sohet F          Influence of coenzyme Q supplementation on inflammation in diet-induced obese mice.


Malou F         The antioxidant CoQ10 prevents uncoupling and restores normal oxygen handling in kidney

                        mitochondria from type-2 diabetic DB/DB mice.


Yamada M    Role of bound quinone in Escherichia coli  quinoprotein glucose dehydrogenase


Saturday, May 29


Cardiovascular Disease 1

Chairpersons: Brohet C and Langsjoen P


08.30              Tiano L

                          Interaction of CoQ10 with endothelium-related biochemical aspects.


08.50             Mortensen SA

                         Status of the Q-SYMBIO study with short-term follow-up results.


09.10              Watts G

                         CoQ and arterial haemodynamics in type 2 diabetes mellitus


09.30              Young J

                         Coenzyme Q10 in the treatment of hypertension:

                         a randomised, double blind, placebo-controlled, cross over study



09.50.- 10.10Discussion

10.10 –10.30Coffee break



Cardiovascular 2

Chairpersons: Van Gaal L  and Belardinelli R


10.30            Langsjoen P

                       Supplemental ubiquinol in the treatment of heart failure; five year experience


10.50            Rosenfeldt F

                       Oxidative Stress and Metabolic therapy in Surgery and cardiovascular  disease


11.10            Golomb B

                       Statins, CoQ10 and mitochondrial function


11.30            Fulop P

                       Clinical experiences with CoQ10


11.50 - 12.30Discussion

12.30 - 14.00 Lunch and Poster Session 2



Mitochondrial myopathies and Neurodegenerative disease

Chairpersons: Beal F and Hirano M


14.00            Hirano M

                       Primary humanCoQ10 deficiencies


14.20            Miles M.

                       Coenzyme Q10 deficiency and mitochondrial defects

                       in children with recurrent food aversion and allergies


14.40            Beal F

                       Coenzyme Q10 and the treatment of neurodegenerative diseases


15.00            Schulz J

                       CoQ10 and idebenone in Friedreich’s Ataxia. 


15.20            Miles L

                       Low percentage of subsarcolemmal mitochondrial aggregates (SSMA) is associated with

                       coenzyme Q10 deficiency in muscle of children with suspected diseases of energy metabolism.


15.30 - 15.50Discussion 

15.50 - 16.10  Coffee break



Biosynthesis

Chairpersons: Stocker R and Dallner G


16.10             Kawamukai M

                        Biosynthetic pathway in fission yeast and other organisms


16.30            Clarke C

                        A conserved START domain coenzyme Q-binding polypeptide is required for respiratory

                        electron transport and antioxidant functions of coenzyme Q


16.50            Santos Ocana C

                        CoQ biosynthesis regulation in yeast through a phosphorylation cycle of Coq7p


17.10             Navas P

                        Transcriptome profile in Coenzyme Q deficiency syndrome


17.30             Dallner G

                        Semisynthetic isoprenoids for increase of coenzyme Q biosynthesis.


17.50            Pierrel F

                       Interconnexion between iron homeostasis and coenzyme Q metabolism in yeast S. cervisiae


18.00 - 18.20       Discussion

20.00                     Social dinner


Sunday, May 30


New findings 1

Chairperson: Balercia G  and Menke T


9.10         Kang KW

                    Protective effect of solubilized coenzyme Q10 on liver fibrosis


9.30         Safarinejad M

                    Efficacy of Coenzyme Q10 Supplementation on Semen Parameters, Sperm Function, and

                    Reproductive Hormone Profiles in Infertile Men:  A Double Blind, Placebo-Controlled, Randomized    

                    Study


9.50            Korkina

                    Clinical and biochemical effects of CoQ10 vitamin E and selenium supplementation to patients

                    with severe erythrodermic and arthropathic psoriasis


10.20         Menke T

                    Changes of CoQ10 during physical exercise. Measurement of CoQ10 in plasma and blood cells in

                    healthy adults undergoing exercise testing by  spiroergometry


10.40 – 11.00  Discussion

11.00 – 11.20       Coffee break




New findings 2

Chairperson: Tiano L and Mancini A


11.20     Padella L

                Prolonged treatment with CoQ10 in Down Syndrome: biochemical and  clinical aspects


11.40    Busciglio J

               The role of oxidative stress and mitochondrial dysfunction in Down’s syndrome


12.00    Littarru C

               Clinical use of CoQ10 in periodontology


12.20 – 13.00Discussion and conclusions

13.00    Lunch